Treatment outcomes in locally advanced colorectal carcinoma

K Harish¹ , YV Narayanaswamy² and S Nirmala³

¹Department of Surgical Oncology, M. S. Ramaiah Medical College & Hospital, Bangalore – 560054, India

²Department of General Surgery, M. S. Ramaiah Medical College & Hospital, Bangalore – 560054, India

³Department of Radiation Oncology, M. S. Ramaiah Medical College & Hospital, Bangalore – 560054, India

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International Seminars in Surgical Oncology 2004, 1:8doi:10.1186/1477-7800-1-8


Published:	4 November 2004

Abstract

Background

Locally advanced colorectal cancers form a distinct subgroup where contiguous organs could be involved without distant metastases and so may be amenable to curative surgical resection. It was our objective to report our experience in treating six such patients with operable locally advanced colorectal carcinomas.

Methods

We retrospectively reviewed the case notes of 47 patients who were diagnosed with colorectal cancers at M S Ramaiah Medical Teaching Hospital between the years 1996 – 2001. Six patients were identified with T4 lesions, adjacent organ involvement and with no nodal involvement. The treatments and outcomes for these patients were then reviewed.

Results

Two of three patients with rectal malignancies who underwent pelvic exenteration succumbed to disease recurrence within the first 18 months. One of the three patients with colonic cancers died of non malignant causes. The other two are disease free till date.

Conclusions

Aggressive multivisceral resections for locally advanced colonic cancers might be appropriate. Rectal cancers when locally advanced may be considered for pelvic exenteration, but a more guarded prognosis may apply.