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Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome

Michael Sand1*, Samuel Uecker1, Falk G Bechara2, Marcos Gelos1, Daniel Sand3, Till H Wiese4 and Benno Mann1

Author Affiliations

1 Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital, Ruhr-University Bochum, Germany

2 Department of Dermatology and Allergology, Ruhr-University Bochum, Germany

3 Department of Physiological Science, University of California Los Angeles (UCLA), USA

4 Department of Radiology, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum, Germany

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International Seminars in Surgical Oncology 2007, 4:15  doi:10.1186/1477-7800-4-15

Published: 2 July 2007


Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C-cells which can secrete adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing factor (CRF) in abnormally high concentrations, potentially causing paraneoplastic Cushing's Syndrome (CS).

We report on a 42-year-old male patient with a ten year history of metastatic medullary thyroid carcinoma suffering from paraneoplastic Cushing's Syndrome caused by ectopic hypersecretion of ACTH and a simultaneous Cortisol producing adrenal metastasis.