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Open AccessCase report

Hemorrhage associated with hepatic artery pseudoaneurysms after regional chemotherapy with floxuridine: case report

Panagiotis Samaras1 email, Thomas Pfammatter2 email and Bernhard C Pestalozzi1 email

Department of Oncology, University Hospital Zurich, Zurich, Switzerland

Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland

author email corresponding author email

International Seminars in Surgical Oncology 2008, 5:17doi:10.1186/1477-7800-5-17

Published: 11 July 2008

Abstract

Pseudoaneurysms of the hepatic artery are a rare complication in patients with primary or secondary liver tumors treated with intra-arterial chemotherapy. We present two patients who developed this complication after placement of a catheter system into the gastroduodenal artery and initiation of regional chemotherapy with floxuridine. Diagnosis was made after symptomatic bleeding occurred, necessitating emergency angiography with coil embolization. Pseudoaneurysms usually occur after mechanical damage of the vessel wall, but the chemical toxicity of floxuridine may add to the development of vascular impairment.


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