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Expression levels of the GEFs studied related to NPI status of the tumours |
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| Guanine Nucleotide Exchange Factors |
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| NPI status |
TRIO |
VAV1 |
TIAM-1 |
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| (NPI < 3.4) |
109 ± 44 |
0.45 ± 0.22 |
1957 ± 1466 |
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| (NPI 3.4–5.4) |
234 ± 113 |
1.18 ± 1.06 |
506 ± 205 |
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| (NPI > 5.4) |
315 ± 176 |
0.45 ± 0.41 |
298 ± 123 |
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NPI = Nottingham Prognostic Index. Levels of Trio showed a sequential increase with increased NPI status with a significant increase from NPI1 to NPI2 (p = 0.04). Expression of Vav1 showed no definitive pattern while TIAM-1 expression showed a sequential decrease with an increase in NPI status. | |||
Lane et al. International Seminars in Surgical Oncology 2008 5:23 doi:10.1186/1477-7800-5-23 |
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