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Breast cancer incidence in Greek women in relation to ABO blood groups and Rh factor

Michael Stamatakos1*, Konstantinos Kontzoglou1, Panagiotis Safioleas1, Constnatinos Safioleas1, Christina Manti2 and Michael Safioleas1

Author Affiliations

1 2nd Department of Propaedeutic Surgery, University of Athens, School of Medicine, LAIKO General Hospital, Athens, Greece

2 Department of Hematology, Thriassio General Hospital, Athens Greece

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International Seminars in Surgical Oncology 2009, 6:14  doi:10.1186/1477-7800-6-14

Published: 18 August 2009

Abstract

Aim

To investigate the correlation between breast cancer in Greek women and ABO blood groups.

Material-methods

In 166 female patients with breast cancer factors such as blood group, histological type, family history, presence or absence of nodal and/or distant metastases were examined. These patients had similar demographic, clinical, surgical, immunohistochemical, laboratory, and follow-up data and this group is representative of general population of women in Greece.

Results

The ductal type of breast cancer was differentially distributed in blood groups Rh (+) (P ≤ 0.001). In patients with A (+) blood group the ductal type of breast cancer was present in 49.6% of cases, in relation to the other blood groups and in AB blood group the same type occurred rarely (3.6%). Rh (+) women with positive family history were more often found in A blood group. The relative risk of metastasis in Rh (-) patients was 4.2 times higher than that in Rh (+) patients. Among Rh (+) patients, the relative risk of metastasis was 1.29 times higher in A blood group than in other blood groups.

Conclusion

Blood group A is often associated with ductal breast cancer (49.6%), in contrast to the other blood groups and particularly to blood group AB (3.6%). Blood group A and, particularly, A (-) has the worst prognosis of all.