Your browser version may not work well with NCBI's Web applications. More information here...
1: Eur J Cancer. 1995 Dec;31A(13-14):2191-5.
Related Articles, Links

Safe selection criteria for breast conservation without radical excision in primary operable invasive breast cancer.

Sibbering DM, Galea MH, Morgan DA, Elston CW, Ellis IO, Robertson JF, Blamey RW.

Nottingham City Hospital, U.K.

In a previous series from this unit of 263 women with primary operable breast cancer treated by macroscopic lumpectomy and breast irradiation, local recurrence was high. An audit at a median follow up of 36 months showed 56 (21%) ipsilateral breast recurrences. Eighteen of these recurrences were aggressive and uncontrolled. Multivariate analysis shows patient age, lymphovascular invasion, tumour size and nodal status to be predictive of local recurrence (Locker AP, et al., Br J Surgery 1989, 76, 890-894). New selection criteria for breast conservation were defined based on these data and also on securing an adequate clear margin of excision. In a subsequent prospective series of 275 women fulfilling these criteria, 6 women (2.2%) developed ipsilateral breast recurrence at the same median follow up of 36 months. In none was this uncontrolled and aggressive. Breast conservation, without radical excision, is safe as long as the selection criteria described are followed.

PMID: 8652241 [PubMed - indexed for MEDLINE]