http://www.issoonline.com The latest research articles published by International Seminars in Surgical Oncology 2009-06-30T00:00:00Z This is an RSS newsfeed from BioMed Central It is intended to be used with an RSS reader. For more information about RSS newsfeeds from BioMed Central, visit http://www.biomedcentral.com/info/about/rss/ Background Independent, strong and unequivocal evidence suggests that life style factors such as obesity and lack of physical activity along with certain reproductive choices can increase the risk of breast cancer. There are no studies measuring the effectiveness of guidelines from the Department of Health regarding life style choices made by women presenting to breast clinics. The aim of this audit was to study the prevalence of obesity, physical activity and reproductive factors in women referred to breast clinic.Patients and methods All patients attending the Breast clinic as new referrals were invited to complete a life style questionnaire. The data was analysed for prevalence of various risk factors for breast cancer. Three hundred and 73 patients completed the questionnaire.Results Final analyses of 373 patients demonstrated that 42% of women performed no exercise and only 24% of patients met Department of Health guideline of 30 minutes of exercise for 5 days a week. Overall 50 % of patients were either obese or overweight and 22% of patients had BMI of >30kg/m2. The median age of menarche was 13 and 18% of women started their period below the age 12. Twenty one percent of women were nulliparous and 14% had their first live birth after the age of 30. Fourteen percent of patients were on the hormone replacement therapy of which 57% have used hormones for more than 5 years. Twenty two percent of women smoked and 9% of women consumed alcohol 5 days a week of which 13% had more than 4 glasses of alcohol in a day.Conclusion There is preponderance of high risk life style choices in women attending breast clinic. If these life style options are not modified, there could potentially be a significant rise in the number of breast cancer in West Midlands. http://www.issoonline.com/content/6/1/12 Amtul Carmichael Laura Harbach Richard Cooke International Seminars in Surgical Oncology 2009, 6:12 2009-06-30T00:00:00Z doi:10.1186/1477-7800-6-12 International Seminars in Surgical Oncology 1477-7800 6 12 2009-06-30T00:00:00Z PDF This article, Int Semin Surg Oncol 2009, 6:4, was submitted to International Seminars of Surgical Oncology without the knowledge or consent of either Prof Karakayali or Prof Haberal, and is being retracted for this reason. An apology is extended to Prof Karakayali and Prof Haberal as well as the editorial and publishing staff and readers of the journal. http://www.issoonline.com/content/6/1/11 Sami Akbulut Ilker Arer Alper Kocbiyik Mahmut Can Yagmurdur Hamdi Karakayali Mehmet Haberal International Seminars in Surgical Oncology 2009, 6:11 2009-04-17T00:00:00Z doi:10.1186/1477-7800-6-11 International Seminars in Surgical Oncology 1477-7800 6 11 2009-04-17T00:00:00Z XML Primitive neuroectodermal tumour (PNET) is a rare tumour mainly found in children under ten years old. It may be broadly categorised into those occurring from the central or peripheral nervous system of which the majority arise centrally. We report a 61 year-old lady who had previous lobular breast cancer presenting with a rapidly expanding lesion in her anterior right upper abdominal wall. Clinically it appeared to be benign, however, histopathology of the excised lesion revealed a localised PNET. This case is an unusual case of a PNET in an adult that is peripheral in nature arising from subcutaneous tissue in the abdominal wall. http://www.issoonline.com/content/6/1/10 Dibendu Betal Behnam Shaygi Ramesh Babu Kamarul Jamil Richard Sainsbury International Seminars in Surgical Oncology 2009, 6:10 2009-03-31T00:00:00Z doi:10.1186/1477-7800-6-10 International Seminars in Surgical Oncology 1477-7800 6 10 2009-03-31T00:00:00Z XML Synovial sarcomas are a rare form of soft tissue sarcomas. We present a case of a 62 year-old male presenting with a left thyroid lump initially though to be a thyroid adenoma but subsequently diagnosed as a monophasic synovial sarcoma of the pharynx. We discuss the diagnosis and treatment of this case. http://www.issoonline.com/content/6/1/9 Dibendu Betal Ramesh Babu Veysi Mehmet International Seminars in Surgical Oncology 2009, 6:9 2009-03-31T00:00:00Z doi:10.1186/1477-7800-6-9 International Seminars in Surgical Oncology 1477-7800 6 9 2009-03-31T00:00:00Z XML Metastasis to the internal auditory canal from breast carcinoma is extremely rare and difficult to diagnose. It radiologically mimics vestibular schwannoma and can occur as a first manifestation of systemic relapse after a long disease-free interval in patients previously treated for early breast cancer. The diagnosis is usually made retrospectively and the optimal management of such metastasis following complete resection remains undefined. http://www.issoonline.com/content/6/1/8 Suat Loo Andrew Dean Philip Murray International Seminars in Surgical Oncology 2009, 6:8 2009-03-31T00:00:00Z doi:10.1186/1477-7800-6-8 International Seminars in Surgical Oncology 1477-7800 6 8 2009-03-31T00:00:00Z XML Background: Nowadays, more breast cancer patients want to have children after the diagnosis of cancer. The purpose of this study is to review the possibility and risks of giving birth among women with breast cancer previously treated by chemotherapy.Case presentationTwo young women aged 28 and 34 respectively, were treated in our clinic for breast cancer, the first (negative hormonal receptors) by surgery, chemotherapy and radiotherapy and the second (positive hormonal receptors) by surgery, radiotherapy and tamoxifen. They both became pregnant, 1 and 8 years after completion of the therapy respectively. Results: Laboratory testing during pregnancy was negative in both cases and after an uneventful course each woman gave birth to a perfectly healthy child. The first patient breastfed her baby for three months, while the second one did not breastfeed her baby at all. Conclusion: Women undergoing chemotherapy for breast cancer can maintain their fertility and get pregnant. Previous chemotherapy for breast cancer does not present any supplementary risks for the child's mental or physical health. http://www.issoonline.com/content/6/1/7 Kontantinos Kontzoglou Michael Stamatakos Sofia Tsaknaki Helen Goga Alkiviades Kostakis Michael Safioleas International Seminars in Surgical Oncology 2009, 6:7 2009-03-02T00:00:00Z doi:10.1186/1477-7800-6-7 International Seminars in Surgical Oncology 1477-7800 6 7 2009-03-02T00:00:00Z XML Background: Cystosarcoma phylloides (CP) is an extremely rare form of breast cancer with an unpredictable clinical course. The histological characteristics of this neoplasm have not proved to offer much in the estimation of prognosis of these patients.Patients and methodsIn our clinics, in a time period of 38 years, 22 patients with cystosarcoma phylloides were treated. There were 5 cases of malignancy, 15 cases with benign tumors, and two cases histologically characterized as borderline neoplasia. Metastases were manifested in one patient. All patients were on a 5-year follow-up, except in five cases, one operated three years ago and four operated within the last two years. Results: 16 of 22 patients did not present any signs of local recurrence or metastases. There were three patients that manifested local recurrence and underwent supplementary ongectomy or mastectomy and are free of recurrence ever since. One patient with metastatic CP died. Conclusion: Independently of its histopathological behavior, CP is a tumor difficult to be treated. Meticulous follow-up is mandatory in order to manage possible recurrence of the neoplasm. http://www.issoonline.com/content/6/1/6 Michael Stamatakos Sofia Tsaknaki Konstantinos Kontzoglou John Gogas Alkiviades Kostakis Michael Safioleas International Seminars in Surgical Oncology 2009, 6:6 2009-02-20T00:00:00Z doi:10.1186/1477-7800-6-6 International Seminars in Surgical Oncology 1477-7800 6 6 2009-02-20T00:00:00Z XML It has been long established that post-mastectomy radiotherapy reduces the risk of locoregional failure. A survival advantage, however, has only recently been demonstrated. We here provide a review of the literature as regards to the current indications for post-mastectomy radiotherapy. http://www.issoonline.com/content/6/1/5 Maria Vilarino-Varela Yaw Sinn Chin Andreas Makris International Seminars in Surgical Oncology 2009, 6:5 2009-02-09T00:00:00Z doi:10.1186/1477-7800-6-5 International Seminars in Surgical Oncology 1477-7800 6 5 2009-02-09T00:00:00Z XML Background: This retrospective study analysed the epidemiological, clinical, and therapeutic profiles of breast cancer in males. Methods: We report our experience at the Hospital of the University of Baskent, where 20 cases of male breast cancer were observed and treated between 1995–2008. Results: Median age at presentation was 66,7 ± 10,9 years. Average follow-up was 63 ± 18,5 months. The main presenting symptom was a mass in 65% of cases (13 patients). Ýnvasive ductal carcinoma was the most frequent pathologic type (70% of cases). Conclusion: Male breast cancer patients have an incidence of prostate cancer higher than would be predicted in the general population. Cause of men have a higher rate of ER positivity the responses with hormonal agents are good. http://www.issoonline.com/content/6/1/4 Sami Akbulut Ilker Arer Alper Kocbiyik Mahmut Can Yagmurdur Hamdi Karakayali Mehmet Haberal International Seminars in Surgical Oncology 2009, 6:4 2009-02-05T00:00:00Z doi:10.1186/1477-7800-6-4 International Seminars in Surgical Oncology 1477-7800 6 4 2009-02-05T00:00:00Z XML Background: Choroidal metastases from gynaecological primary are extremely rare. There is no documented case in the literature of choroid metastasis in a patient with primary peritoneal carcinoma (PPC).Methods & ResultsWe describe the first case of a 54-year-old woman with a history of borderline mucinous tumour who presented 17 months later with PPC and 21 months after with recurrent disease metastatic to the eye, and review pertinent literature. Conclusion: High index of suspicion is warranted when patients with history of primary peritoneal carcinoma present with visual complaints in order to treat and/or relieve symptomatology from metastatic eye disease. http://www.issoonline.com/content/6/1/3 Nikolaos Thomakos Khandra Galaal Georgios Georgopoulos Lakshmi Nagaraju Dianne Hemming Raj Naik International Seminars in Surgical Oncology 2009, 6:3 2009-01-20T00:00:00Z doi:10.1186/1477-7800-6-3 International Seminars in Surgical Oncology 1477-7800 6 3 2009-01-20T00:00:00Z XML